Materials Frontier No.137
Title: Nano-Engineered Biomaterials Prevent Device-Associated Infection Through Immunomodulation
Speaker: Bingyun Li, Associate Professor, Department of Orthopaedics, School of Medicine,West VirginiaUniversity
Biomaterial-associated infection is one of the most common and problematic complications faced by millions of patients worldwide. The current antibiotic therapy strategies face challenges, the most serious of which are antibiotic resistance and intracellular persistence. Studies have shown that the systemic level of interleukin 12p70 (IL-12) decreases following major injuries resulting in decreased cell-mediated immune response. IL-12, a natural cytokine, plays a central role in cell-mediated immune response and bridges innate and adaptive immunities. In this presentation, IL-12 nanocoatings and microcapsules were developed using layer-by-layer nano-assembly, and their efficacy in preventing biomaterial-associated infection was examined. We found that IL-12 nanocoatings and microcapsules were effective in reducing infection in an open femur fracture rat model and were advantageous compared to conventional treatments including percutaneous and systemic injections. Moreover, exogenous IL-12 had additive effects in prophylaxis of infection in combination with conventional treatment (i.e. antibiotic therapy). In addition, nanoparticles targeting intracellular pathogens and nanoencapsulation of platelet rich plasma were briefly discussed. Our approaches could be a revolutionary step toward preventing biomaterial-associated infections using nonantibiotic (e.g. immunomodulation) treatments.
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