INTRODUCTION

Qianjun HE is a professor and academic leader of the Center of Hydrogen Science of Shanghai Jiao Tong University (SJTU), appointed a Distinguished Professor of Shenzhen Research Institute of SJTU and the Director of the R&D Center, and awarded a Marie Curie Fellow by EU. He has engaged in the research of biomedical nanomaterials for >20 years, pioneered a unique research field of Gas Nanomedicine, originally discovered the biological target of hydrogen molecule, developed the first hydrogen bio-probe, and proposed a concept of hydrogenothermal therapy for the first time. He has published 100+ papers on international leading journals including Science Advances, Nature Communications, Advanced Materials, Angewandte Chemie, National Science Review, and Chemical Society Reviews, achieving an h-index of 58. He was recognized as a “Highly Cited Researcher” in 2018 and as a “World’s Top 2% Scientists” with Career Scientific Impact in 2022-2022. He was awarded lots of prizes including EU Marie Curie International Incoming Fellowship, "LU JiaXi" Youth Talent Award of Chinese Academy of Sciences, 2018 Science Stars of China, etc. He is sitting the Associate Editors of Medical Gas Research, and Chemical Synthesis.

EDUCATION AND WORK EXPERIENCE

Jan 2022 ~ Present, Professor, PI, Chief of Lab of Hydrogen Medicine

Center of Hydrogen Science, School of Materials Science and Engineering, Shanghai Jiao Tong University.

Jul 2015 ~ Dec 2021, Professor, PI, Chief of Lab of Advanced Nanomedicine

School of Biomedical Engineering, Health Science Center, Shenzhen University, P. R. China.

Nov 2014 ~ Jul 2015, Post-doc Research Fellow (Group Leader: Prof. Xiaoyuan Shawn Chen)

National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, USA.

Sep 2012 ~ Sep 2014, Marie Curie Fellow           (Group Leader: Prof. Fiona C. Meldrum)

School of Chemistry, University of Leeds, United Kingdom.

Jul 2010 ~ Sep 2012, Assistant Professor            (Group Leader: Prof. Jianlin Shi)

State Key Lab of High Performance Ceramics and Superfine Microstructure,

Shanghai Institute of Ceramics (SIC), Chinese Academy of Sciences (CAS), P. R. China.

Sep 2007 ~ Jul 2010, Ph.D. in Materials Physics and Chemistry      (Supervisor: Prof. Jianlin Shi)

State Key Lab of High Performance Ceramics and Superfine Microstructure,

Shanghai Institute of Ceramics (SIC), Chinese Academy of Sciences (CAS), P. R. China.

Sep 2004 ~ Jul 2007, Research-based M.Sc. in Materials Science (Supervisor: Prof. Zhi-Liang Huang)

Materials Science & Engineering Department, Wuhan Institute of Technology, P. R. China.

Sep 2000 ~ Jul 2004, B.Sc. in Polymer Materials Science & Engineering

Materials Science & Engineering Department, Wuhan Institute of Technology, P. R. China.

RESEARCH INTERESTS

(1) Innovative nanomedicines for precision gas therapy, involving therapeutic gas molecules including H2, CH4, NO, CO and H2S, targeted gas delivery, controlled gas release, and combination therapy based them

(2) Gas activation for tissue engineering: Stem cell therapy, bone and cartilage repair, wound healing, myocardial infarction recovery, etc.

(3) Gas regulation of diseased microenvironments, involving tumor microenvironment and arthritic synovial microenvironment, and the regulations of immunity, inflammation, intestinal flora, and hypoxia

(4) Nano-catalytic gas medicine: the development of photo-/sono-/eletro-/magneto-/microwave-catalytic gas-releasing nanocatalysts, and their biomedical applications

(5) Biological mechanisms of H2 and CH4 and them-based rational drug design

SELECTED PUBLICATIONS

1. Shengqiang Chen,# Yuanman Yu,# Songqing Xie,# Danna Liang, Wei Shi, Sizhen Chen, Guanglin Li, Wei Tang,* Changsheng Liu,* Qianjun He*, Local sustained H2 release remodels senescence microenvironment for improved repair of injured aging bone, Nature Aging, 2023, under review after revision.

2. Qingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia, Lingting Zeng, Xiaoqing Cai, Zhaokui Jin, Shucun Qin*, Wenjiang Ding, Qianjun He*, Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing, National Science Review, 2023, 10, nwad063.

3. Shengqiang Chen,# Yanxia Zhu,# Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, Xishen Xu, Zhaokui Jin, Qianjun He*, Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing, Nature Communications, 2022, 13, 5684.

4. Bin Zhao,# Lingting Zeng,# Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang*, Qianjun He*, NIR-photocatalytic regulation of arthritic synovial microenvironment, Science Advances, 2022, 8, eabq0959.

5. Zhaokui Jin, Penghe Zhao, Wanjun Gong, Wenjiang Ding, Qianjun He*, Fe-porphyrin: a redox-related biosensor of hydrogen molecule, Nano Research, 2023, 16, 2020.

6. Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu*, Qianjun He*, An activity-based ratiometric fluorescent probe for in vivo real-time imaging of hydrogen molecules, Angewandte Chemie International Edition, 2022, 61, e202114594.

7. Yangsen Xu,# Mingjian Fan,# Wenjuan Yang, Yonghao Xiao, Lingting Zeng, Xiao Wu, Qinghua Xu, Chenliang Su*, Qianjun He*, Homogenous carbon/potassium-incorporation strategy for synthesizing red polymeric carbon nitride capable of near-infrared-photocatalytic H2 production, Advanced Materials, 2021, 33, 2101455.

8. Danyang Chen,# Zhaokui Jin,# Bin Zhao, Yingshuai Wang, Qianjun He*, MBene as a theranostic nanoplatform for photocontrolled intratumoral retention and drug release, Advanced Materials, 2021, 33, 2008089.

9. Bin Zhao,# Yingshuai Wang,# Xianxian Yao, Danyang Chen, Mingjian Fan, Zhaokui Jin, Qianjun He*, Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst, Nature Communications, 2021, 12, 1345.

10. Xiang Ling,# Zhaokui Jin, # Qi Jiang, Xiaotao Wang, Bin Wei, Zhongchang Wang, Yangsen Xu, Tianye Cao, Jonathan W. Engle, Weibo Cai, Chenliang Su*, Qianjun He*, Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform, National Science Review, 2021, 8, nwaa156.

11. Yingshuai Wang,# Tian Yang,# Qianjun He*, Strategies for engineering advanced nanomedicines for gas therapy of cancer, National Science Review, 2020, 7, 1485–1512.

12. Jin Meng,# Zhaokui Jin,# Penghe Zhao, Bin Zhao, Mingjian Fan, Qianjun He*, A multistage assembly/disassembly strategy for tumor-targeted CO delivery, Science Advances, 2020, 6, eaba1362.

13. Bo Yu, Dalong Ni, Zachary T. Rosenkrans, Todd E. Barnhart, Hao Wei, Carolina A. Ferreira, Xiaoli Lan, Jonathan W. Engle, Qianjun He*, Faquan Yu, and Weibo Cai*, A “missile-detonation” strategy to precisely supply and efficiently amplify Cerenkov radiation energy for cancer theranostics, Advanced Materials, 2019, 31, 1904894.

14. Penghe Zhao,# Zhaokui Jin,# Qian Chen, Tian Yang, Danyang Chen, Jin Meng, Xifeng Lu, Zhen Gu*, Qianjun He*, Local generation of hydrogen for enhanced photothermal therapy, Nature Communications, 2018, 9, 4241.

RESEARCH PROJECTS

4 ongoing research projects including 2 National Natural Science Foundation of China; >10 research projects completed

HONORS & AWARDS

1.     2022 Distinguished Leadership in Molecular Hydrogen Research

2.    2020-2022 World’s Top 2% Scientists

3.    2018 Highly Cited Researcher

4.    2018 Science Stars of China

5.    2017 Universal Scientific Education and Research Network (USERN) Prize

6.    2015 “Peacock Plan” or Oversea High-Caliber Personnel (Level B)

7.    2012 Marie Curie International Incoming Fellowship

8.    2012 "LU JiaXi" Youth Talent Award of Chinese Academy of Sciences (Top 50)

9.    Member of CAS Society for Promotion of Youth Innovation (2012−2015)

10.  2011 Top-Class President Award of Chinese Academy of Sciences (Top 40)