Introduction
Dr. Guangyin Yuan is a tenured professor of School of Materials Science and Engineering at Shanghai Jiao Tong University. Dr. Yuan received his Ph.D. in Materials Science and Engineering from Southeast University, China in 1999. He then did his postdoctoral research at Shanghai Jiao Tong University and focused on the development of heat-resistant magnesium alloys for automobile powertrain applications. He was promoted to associate professor in Shanghai Jiao Tong University in 2002. Then he went to Tohoku University, Japan, and worked as a JSPS researcher from 2002 to 2004, where he focused on the study of bulk metallic glasses and advanced magnesium alloys reinforced with in-situ quasicrystals. He was promoted to professor in 2008 and tenured professor in 2016, respectively. His research fields are mainly involved in the design of advanced materials and correlation between the microstructure and properties of metallic materials, and in recent ten years his research focused on the research and development of novel biodegradable metals (Mg、Zn、Fe-based) alloys for medical applications. He has published over 120 journal papers in international journals and owns 20 patents including 16 patents related to biomaterials and related medical devices.
Biographical Information
Education:
Sep.1996-Feb. 2000, Southeast University, China, Material Processing Engineering, Ph.D
Sep.1993-July 1996, Shenyang University of Technology, China, Material Processing Engineering, M.E.
Sep.1989-July 1993, Shenyang Institute of Technology, China, Material Processing Engineering, B.E.
Professional Appointments:
Aug.2016- present, Tenured Professor
School of Materials Science and Engineering, Shanghai Jiao Tong Univ. China
Vice director of National Engineering Research Center of Light Alloy Net Forming, China.
Director of Biomaterials Research Center of School of Mater Sci & Eng, SJTU.
Dec.2008- Aug.2016, Professor
School of Materials Science and Engineering, Shanghai Jiao Tong Univ. China
Dec.2001-Dec.2008, Associate Professor
School of Materials Science and Engineering, Shanghai Jiao Tong Univ. China
Sep.2002-Sep.2004, Japan Society for the Promotion of Science(JSPS) Research Fellowship, Inoue Lab, Institute of Materials Research, Tohoku University, Japan
Mar.2000-Dec.2001, Post-doctor fellowship
School of Materials Science and Engineering, Shanghai Jiao Tong Univ. China
Professional Memberships:
1. Vice Chairman of Medical Metals Branch of Chinese Society For Biomaterials (2019.11-2023. 10)
2. Vice Chairman of The Corrosion Control Branch of Medical Metal Materials of Chinese Society for Corrosion and Protection(2021.7-2025.6)
3. Executive director of Cardiovascular Materials Branch of Chinese Society For Biomaterials (2019.10-2023.9)
4. Executive director of the Youth Committee, Chinese Materials Research Society (2013.6-2014.12)
5. Scientific Committee Member of 10th International conference on processing & manufacturing of advanced materials, Processing, Fabrication, Properties, Applications (Thermec2018)
6. International Advisory Committee Member of 11th International conference on processing & manufacturing of advanced materials, Processing, Fabrication, Properties, Applications (Thermec 2021)
Research Interests
1. Research & Development of biodegradable Medical Metals (Bio-Mg，Bio-Zn) with high strength & ductility and suitable biodegradation rate as well as good biocompatibility.
2. Design and synthesis of surface functional coating for biodegradable Medical Metals.
3. Design and fabrication of biomedical devices.
4. Interaction of materials and cells and their underlying mechanisms（the scope of study including the orthopaedic implants and cardiovascular stents, etc.）
Selected Publications
（2015-） (More than 150 publications in peer reviewed journals and cited by about 5500 times; please find details here: Scopus Author ID: 7201553593)
1．JL Niu, H Huang, J Pei, ZH Jin, SK Guan, GY Yuan*, Research and development strategy for biodegradable magnesium-based vascular stents: a review. Biomater Transl. 2021, 2(3), 236-247.
2．Yinchuan Wang, Hua Huang, Gaozhi Jia, Hui Zeng*, Guangyin Yuan*，Fatigue and dynamic biodegradation behavior of additively manufactured Mg scaffolds，Acta Biomater，135（2021）705-722
3．Shihao Fan, Rui Yue, Song Li, Guangyin Yuan*, Zhaohui Jin*, First‑principles calculations of diffusion activation energies for designing anti‑self‑aging biodegradable zinc alloys，Journal of Materials Research 2021, 36(7), pp. 1475–1486
4．Chun Chen, Hua Huang*, Jialin Niu, Jian-Feng Nie*, Guangyin Yuan*, Origin of high tension-compression yield asymmetry in as-extruded pure zinc, Scripta Materialia 200 (2021) 113922
5．Jimiao Jiang, Hua Huang*, Jialin Niu, Zhaohui Jin, Matthew Dargusch, Guangyin Yuan*, Characterization of nano precipitate phase in an as-extruded Zn-Cu alloy, Scripta Materialia，200 (2021) 113907
6．Jinzhou Zhu, Xiyuan Zhang, Jialin Niu, Yongjuan Shi, Zhengbin Zhu, Daopeng Dai, Run Du, Zhenkun Yang, Jian Hu, Fenghua Ding, Chenxin Chen, Jia Pei, Guangyin Yuan*, Ruiyan Zhang* Biosafety and Efficacy Evaluation of a Biodegradable Magnesium based Drug-eluting Stent in Porcine Coronary Artery, Scientific Reports, 2021, 11(1), 7330
7．Kai Xie , Lei Wang, Yu Guo, Shuang Zhao, Yangzi Yang, Disheng Dong ,Wenjiang Ding , Kerong Dai, Weihua Gong**, Guangying Yuan***, Yongqiang Hao*，Effectiveness and safety of biodegradable Mg-Nd-Zn-Zr alloy screws for the treatment of medial malleolar fractures，Journal of Orthopaedic Translation 27 (2021) 96–100
8．Mingyu You, Monica´ Echeverry-Rendon, Lei Zhang, Jialin Niu, Jian Zhang, Jia Pei*, Guangyin Yuan*，Effects of composition and hierarchical structures of calcium phosphate coating on the corrosion resistance and osteoblast compatibility of Mg alloys. Mater Sci Eng C 120(2021) 111734
9．K Zhou, YT Li, L Zhang, L Jin, F Yuan, JY Tan*, GY Yuan*, J Pei*, Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium, Bioactive Materials, 6(1)(2021): 262-272
10. Hongwei Miao, Hua Huang, Shihao Fan, Jinyun Tan, Zhongchang Wang*, Wenjiang Ding, Guangyin Yuana*，Nanoscale Precipitations in Deformed Dilute Alloying Mg-Zn-Gd Alloy, Materials and Design, 2020, 196, 109122
11. Chun Chen , Rui Yue , Jian Zhang , Hua Huang *, Jialin Niu *, Guangyin Yuan*, Biodegradable Zn-1.5Cu-1.5Ag alloy with anti-aging ability and strain hardening behavior for cardiovascular stents，Mater Sci & Eng C.（2020）116,111172.
12. Zhe Wang, Xinyuan Wang, Yuan Tian, Jia Pei, Jian Zhang, Chang Jiang, Junming Huang, Zhiying Pang, Yuanwu Cao, Xiuhui Wang, Senbo An, Xiao Wang, Hua Huang***, Guangyin Yuan**, Zuoqin Yan*, Degradation and Osteogenic Induction of a SrHPO4-coated Mg–Nd–Zn–Zr Alloy Intramedullary Nail in a Rat Femoral Shaft Fracture Model, Biomaterials, 247（2020）119962
13．Lei Zhang, Gaozhi Jia, Min Tang, Chenxin Chen, Jialin Niu, Hua Huang, Bin Kang, Jia Pei*, Hui Zeng, Guangyin Yuan*，Simultaneous enhancement of anti-corrosion, biocompatibility and antimicrobial activities by hierarchically-structured brushite/Ag3PO4-coated Mg-based alloy scaffolds，Mater Sci & Eng C. 111(2020) 110779.
14. L Jin, CX Chen, GZ Jia, YT Li, J Zhang, H Huang, B Kang, GY Yuan*, H Zeng*, TX Chen*, The bioeffects of degradable products derived from a biodegradable Mg-based alloy in macrophages via heterophagy, Acta Biomater, 106(2020)428-438.
15. Yinchuan Wang, Penghuai Fu, Nanqing Wang, Liming Peng, Bin Kang, Hui Zeng, Guangyin Yuan*, Wenjiang Ding，Challenges and Solutions for Additive Manufacturing of Biodegradable Magnesium Implants，Engineering，6（2020）1267-1275.
16. Wei Wang, Gaozhi Jia, Qing Wang, Hua Huang, Xiaolin Li, Hui Zeng, Wenjiang Ding, Frank Witte, Changqing Zhang*, Weitao Jia*, Guangyin Yuan*, The in vitro and in vivo biological effects and osteogenic activity of novel biodegradable porous Mg alloy scaffolds, Materials and Design, 189(2020)108514
17. Chenxin Chen, Jiahui Chen, Wei Wu, Yongjuan Shi, Liang Jin, Lorenza Petrini, Li Shen, Guangyin Yuan,* Wenjiang Ding, Junbo Ge, Elazer R. Edelman, Francesco Migliavacca*, In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy, Biomaterials 221 (2019) 119414
18. Liang Jin, Chenxin Chen, Yutong Li, Feng Yuan, Ruolan Gong, Jing Wu,Hua Zhang, Bin Kang, Guangyin Yuan*, Hui Zeng* and Tongxin Chen*，A Biodegradable Mg-Based Alloy Inhibited the Inflammatory Response of THP-1 Cell-Derived Macrophages Through the TRPM7–PI3K–AKT1 Signaling Axis，Frontiers in Immunology 10(2019), Article 2798
19. Jian Zhang, Haiyang Li, Wu Wang，Hua Huang, Jia Pei, Haiyun Qu，Guangyin YUAN*, Yongdong Li, The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: a 20-month study, Acta Biomater., 69(2018)372-384.
20. Guoyuan Li, Lei Zhang, Lei Wang, Guangyin Yuan, Kerong Dai, Jia Pei*, Yongqiang Hao*, Dual modulation of bone formation and resorption with zoledronic acidloaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study, Acta Biomater. 65（2018）486-500.
21. Chenxin Chen, Jinyun Tan, Wei Wu, Lorenza Petrini, Lei Zhang, Yongjuan Shi, Emanuele Cattarinuzzi, Jia Pei, Hua Huang, Wenjiang Ding, Guangyin Yuan, Francesco Migliavacca，Modeling and experimental studies of coating delamination of biodegradable magnesium alloy cardiovascular stents，ACS Biomaterials Science & Engineering，4(11),2018 pp. 3864-3873
22. Gaozhi Jia, Chenxin Chen, Jian, Zhang, Bérengère J.C. Luthringer - Feyerabend, Regine Willumeit-Roemer, Hua Zhang, Meiping Xiong, Hua Huang, Guangyin Yuan*，F